Improved Synthetic Procedures for 4,7,2‘,7‘-Tetrachloro- and 4‘,5‘-Dichloro-2‘,7‘-dimethoxy-5(and 6)-carboxyfluoresceins

Autor:	Matthew H. Lyttle, and Tim G. Carter, Ronald M. Cook
Rok vydání:	2000
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Resorcinol Physical and Theoretical Chemistry Combinatorial chemistry
Zdroj:	Organic Process Research & Development. 5:45-49
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op000292o
Popis:	Literature syntheses of 4,7,2‘,7‘-tetrachloro-5(and 6)-carboxy-fluorescein (“5 and 6 TET”) 1 and 4‘,5‘-dichloro-2‘,7‘-dimethoxy-5(and 6)-carboxyfluorescein (“5 and 6 JOE”) 2 are reviewed, and new, preparatively useful methods are presented. A three-step synthesis of 1 was developed, which proved to be more efficient than the published seven step synthesis of this compound. The published synthesis of 2 also proved difficult to reproduce, and a better workup of the key intermediate 2-chloro-4-methoxy resorcinol was devised. Isolation of purified single isomers of both dyes is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::82b0e6a832b24007d7154d8dc0d56ca8 https://doi.org/10.1021/op000292o Zobrazit plný text záznamu