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Seven new alkaloids, kuroshines C–G (1–5), 3β-hydroxyzoanthenamide (6), 7α-hydroxyzoanthenamide (7), along with a known compound, zoanthenamine (8), were isolated from the ethanolic extract of Formosan zoanthid Zoanthus kuroshio. Kuroshines C–G (1–5) are alkaloids possess a densely functionalized ring system on the basis of the zoanthamine framework, and compounds 6 and 7 may be categorized as zoanthenamide derivatives with an additional hydroxyl substitution. The structures of these compounds were determined through the interpretation of mass and spectroscopic methods, especially 2D NMR analyses. The anticancer activities of the isolates against melanoma cell line B16 were evaluated. |
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