Effects of Phosgene Exposure on Bacterial, Viral, and Neoplastic Lung Disease Susceptibility in Mice
| Autor: | Mary J. Daniels, Judith A. Graham, Joseph W. Illing, Diane M. Starnes, MaryJane K. Selgrade |
|---|---|
| Rok vydání: | 1989 |
| Předmět: | |
| Zdroj: | Inhalation Toxicology. 1:243-259 |
| ISSN: | 1091-7691 0895-8378 |
| DOI: | 10.3109/08958378909145231 |
| Popis: | In this study the effects of phosgene inhalation on host resistance models representative of bacterial, viral, and neoplastic lung diseases were assessed. A single Ch exposure to concentrations of phosgene of 0.025 ppm and above significantly enhanced mortality due to laboratory-induced aerosol infection with Streptococcus zooepidimi-cus (group C). Bacteria recovered from lavage fluid of mice exposed to 0.05 ppm for 4 h increased dramatically between 3 and 48 h post infection, while bacteria recovered from lavage fluid of air exposed mice declined to nearly undetectable levels over the same time period. Concentrations of phosgene 10-fold higher than the lowest observable effect concentration for streptococcus susceptibility had little or no effect on alveolar macrophage phagocytic activity and little or no effect on total cells recovered, viability, or differential cell counts in lavage fluid obtained shortly after exposure. A single 4-h exposure to as little as 0.025 ppm phosgene also caused a si... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|