Effect of low-dose warfarin on D-dimer levels during sickle cell vaso-occlusive crisis: a brief report
| Autor: | Uzma Iqbal, Manish Sheth, Anita K. Siddiqui, Shahid Ahmed, Rabia K. Shahid, Cristina Sison, Linda A. Russo, Dilip Patel |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Blood transfusion business.industry Anemia medicine.medical_treatment Warfarin Hematology General Medicine medicine.disease Gastroenterology Surgery medicine.anatomical_structure White blood cell Internal medicine D-dimer medicine Hemoglobin F Hemoglobin business Vaso-occlusive crisis medicine.drug |
| Zdroj: | European Journal of Haematology. 72:213-216 |
| ISSN: | 0902-4441 |
| DOI: | 10.1111/j.0902-4441.2003.00209.x |
| Popis: | Objective : To evaluate the activation of clotting systems in patients with sickle cell disease (SCD) by measuring the plasma D-dimer level and to determine the effect of low-dose warfarin on D-dimer level during vaso-occlusive crisis. Methods : Plasma D-dimer level was measured in 65 blood samples of 37 adult patients with SCD who were hospitalized for vaso-occlusive painful crisis. D-dimer level of patients who were on low-dose warfarin was compared with those patients who were not on any anticoagulation treatment. Analysis of variance (anova) was carried out to determine factors significantly associated with low D-dimer level in patients with SCD. The following factors were included in the anova model; warfarin, homozygous hemoglobin S, history of blood transfusion in past 3 months, hydroxyurea, hemoglobin S%, hemoglobin F%, white blood cell counts, hemoglobin level, platelet count, and plasma fibrinogen level. Results : Overall median D-dimer level in 65 samples was 2.7 μg fibrinogen equivalent units (FEU)/mL (0.34–4). Patients who were on low-dose warfarin had a median D-dimer level of 0.81 μg FEU/mL (0.34–1.8) compared with 3.1 μg FEU/mL (0.94–4) in those patients who were not on anticoagulation treatment. Using anova to model D-dimer levels, only warfarin was significantly correlated with low D-dimer levels after controlling for other variables. Conclusions : Patients with SCD during vaso-occulsive painful crisis have an elevated D-dimer level. Low-dose anticoagulation treatment is associated with a significant reduction in the D-dimer levels. |
| Databáze: | OpenAIRE |
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