Enhancement of Anticancer Activity of N(4)1-(2-Pyridyl)piperazinyl 5-Nitroisatin Thiosemicarbazone on Chelation with Copper(II)
| Autor: | Yuba Raj Pokharel, Ravinder Kumar Choudhary, Anupa A. Kumbhar, Narendra Kumar Singh, Nerina Shahi, Paras Nath Yadav, Smriti Shrestha |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Asian Journal of Chemistry. 33:557-564 |
| ISSN: | 0975-427X 0970-7077 |
| Popis: | 5-Nitroisatin-4-(1-(2-pyridyl)piperazinyl)-3-thiosemicarbazone (Nitistpyrdlpz) and its Cu(II) complex were synthesized and characterized by CHN and thermal analysis and spectroscopic measurements viz. UV-vis, FTIR, 1H NMR, 13C NMR, ESI-HRMS, PXRD and EPR. In the complex, copper(II) ion is coordinated by terdentate thiosemicarbazone anion and one chloride ion in a distorted square planar geometry. The synthesized compounds against breast cancer cell lines; MCF-7 and MDA-MB-231 and epidermoid carcinoma; A431 showed that the complex contributed to reduce the percentage of cell viability toward all the tested cell lines but remarkable contribution toward MDA-MB-231 cell line. The IC50 of the complex and free ligand was found in the range of IC50 0.85-1.24 μM and IC50 3.28-3.53 μM, respectively. Among those cell lines, the complex may be the better anticancer agent toward MDA-MB-231 because of its action at micromolar concentration (IC50 0.85 μM). |
| Databáze: | OpenAIRE |
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