Fluorinated NH-iminophosphonates in synthesis of biorelevant α-aminophosphonic acids derivatives
| Autor: | Yulia Rassukana, Ivanna Yelenich, Petro Onysʹko |
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| Rok vydání: | 2022 |
| Zdroj: | Ukr. Bioorg. Acta 2022, Vol. 17, N1. 17:101-104 |
| ISSN: | 1814-9766 1814-9758 |
| DOI: | 10.15407/bioorganica2022.01.101 |
| Popis: | Reactions of (poly)fluoroalkylated NH-iminophosphonates with nitromethane, trimethylsilylcyanide, and diphenylphosphine oxide lead to respective fluorinated β-nitro-α-aminophosphonates, α-cyano-α-aminophosphonates, and heminal bisphosphonates. Reaction with 3-aminocrotonitrile 5 proceds at the β-position of enamine. In the case of α-imino chlorodifluoroethylphosphonate 1c the reaction is accompanied by an unusual nucleophilic substitution of the chlorine atom in CF2Cl group with the formation of pyrroline bearing a difluoromethylated aminophosphonate moiety |
| Databáze: | OpenAIRE |
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