Tools for Drug Discovery: Natural Product-based Libraries

Autor: S. Grabley, I. Sattler, R. Thiericke
Rok vydání: 2000
Předmět:
Zdroj: The Role of Natural Products in Drug Discovery ISBN: 9783662040447
DOI: 10.1007/978-3-662-04042-3_8
Popis: About 30% of the drugs sold worldwide are based on natural products. Though recombinant proteins and peptides account for an increasing market volume, the superiority of low-molecular-mass compounds in human disease therapy remains undisputed, due mainly to more favorable compliance and bioavailability properties. In the past, new therapeutic approaches have often evolved from research involving natural products. Numerous examples from medicine impressively demonstrate the innovative potential of natural compounds and their impact on progress in drug discovery and development. However, natural products are currently undergoing a phase of reduced attention because of the enormous effort which is necessary to isolate the active principles and to elucidate their chemical structures.
Databáze: OpenAIRE