Association of MEG3 Hypermethylation and MiR-21 Upregulation with the Incidence in Iraqi Acute Myeloid Leukaemia Patients
| Autor: | Noha Mohammed Saleh, Hameed Majeed Jasim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
MEG3 medicine.medical_specialty business.industry Cognitive Neuroscience Incidence (epidemiology) Atomic and Molecular Physics and Optics Developmental Neuroscience Downregulation and upregulation hemic and lymphatic diseases Internal medicine DNA methylation medicine Myeloid leukaemia business |
| Zdroj: | NeuroQuantology. 19:122-128 |
| ISSN: | 1303-5150 |
| DOI: | 10.14704/nq.2021.19.6.nq21077 |
| Popis: | Background: Acute myeloid leukaemia (AML) can be defined as a hematologic malignancy that distinguished by genetic defects and epigenetics alterations. LncRNA MEG3 was shown to play the role of tumour suppressor, and play a pivotal role in leukemogenesis, MEG3 hypermethylation has been reported to be related to different types of haematological malignancies. MIR-21 is regarded as a significant miRNA, it considered to play a vital role in AML progressions. Results: The levels of methylation in the MEG3 promoter region in AML patients were significantly increased than in healthy controls, as the MEG3 expression levels were significantly lowered (P ≤ 0.05) in AML patients in contrast with healthy controls. On the other hand, results showed elevated expression levels of miR-21 in AML patients compared with healthy controls. Conclusion: The present study indicates that the hypermethylation of MEG-3 promoter region could explain MEG-3 expression level loss. Our findings also revealed that the overexpression of miR-21 supports its function as an oncogene. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|