Supervised Exercise Training Reduces Plasma Levels of the Endothelial Inflammatory Markers E-Selectin and ICAM-1 in Patients With Peripheral Arterial Disease

Autor:	T. Lyberg, Einar Stranden, Jonny Hisdal, T. Saetre, Jon Otto Sundhagen, J.J. Jørgensen, E. Enoksen
Rok vydání:	2011
Předmět:	ICAM-1 medicine.medical_specialty biology business.industry Arterial disease Vascular inflammation Plasma levels Peripheral Internal medicine E-selectin Immunology medicine biology.protein Cardiology In patient Cardiology and Cardiovascular Medicine business Supervised exercise
Zdroj:	Angiology. 62:301-305
ISSN:	1940-1574 0003-3197
Popis:	Elevated plasma levels of vascular inflammatory markers have been reported in patients with peripheral arterial disease (PAD). We assessed the effect of supervised exercise training (ET) on vascular inflammation, hypothesizing that ET reduces plasma levels of the endothelial adhesion molecules E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1). Twenty-nine patients with PAD underwent a supervised ET program for 8 weeks. Before and after ET, walking distances (pain-free, PWD; maximal, MWD) were determined by a standard treadmill test. Plasma levels of E-selectin and ICAM-1 were significantly reduced (E-selectin: 45.5-40.4 ng/mL, P = .013); ICAM-1: 342.0-298.0 ng/mL, P = .016). VCAM-1 levels were unchanged. Walking distances increased significantly (PWD: median 77-150 m, P < .001; MWD: median 306-535 m, P < .001). In conclusion, 8 weeks of ET in patients with PAD reduces plasma levels of the specific endothelium-derived inflammatory markers E-selectin and ICAM-1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::827998e157404e7d049bd320adcd3a8c https://doi.org/10.1177/0003319710385338 Zobrazit plný text záznamu