Preparation of a chiral azadiene for the synthesis of 5-aza analogues of angucyclinones

Autor:	Drissa Sissouma, Sylvain Collet, Geoffroy Dequirez, André Guingant
Rok vydání:	2011
Předmět:	Chemistry Organic Chemistry Drug Discovery Organic chemistry Ester hydrolysis Enantiomer Biochemistry
Zdroj:	Tetrahedron Letters. 52:2336-2339
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2011.02.084
Popis:	We have developed an efficient synthesis of both enantiomers of a key azadiene for the preparation of 5-aza analogues of angucyclinones through a hetero Diels–Alder reaction. These dienes were efficiently prepared via a 4-step procedure from known and readily available chiral diketoesters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8278283539e533ed4610ad4ff2e12f5e https://doi.org/10.1016/j.tetlet.2011.02.084 Zobrazit plný text záznamu Full Text from ScienceDirect