Atypical BCL6/GATA3+ Primary Cutaneous Acral CD8-Positive T-Cell Lymphoma: A Diagnostic Challenge
| Autor: | Miguel A. Piris, Diana Camacho-García, Lucía Prieto-Torres, Luis Requena, Socorro María Rodríguez-Pinilla |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Solitary pulmonary nodule CD68 business.industry Dermatology General Medicine medicine.disease BCL6 Cutaneous lymphoma Pathology and Forensic Medicine Lymphoma 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases medicine T-cell lymphoma Histopathology Differential diagnosis business |
| Zdroj: | The American Journal of Dermatopathology. 43:137-140 |
| ISSN: | 0193-1091 |
| Popis: | Primary cutaneous acral CD8-positive T-cell lymphoma consists of slow-growing nodules in acral sites with a histopathology, suggesting high-grade lymphoma despite the indolent clinical course. It has been recently included in WHO-EORTC classification for primary cutaneous lymphomas as a provisional entity. A correct diagnosis of this entity is important because its differential diagnosis include more aggressive cutaneous lymphomas. We present a 53-year-old woman with an indolent solitary nodule on her right leg, which histopathologically showed features of CD8-positive T-cell lymphoma, although with some peculiarities, including epidermotropism, absence of CD68 expression, and positivity for GATA3 and Bcl6 in neoplastic cells. This case could contribute to better define the spectrum of this rare cutaneous lymphoma. |
| Databáze: | OpenAIRE |
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