Effect of a Single Oral Dose of Sumatriptan on Paracetamol Pharmacokinetics
| Autor: | P. Usha Rani, J. C. Shobha, K. Ravi Sekhar, E. Chandra Sekhar, T Ramesh Kumar Rao, M. U. R. Naidu |
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| Rok vydání: | 1995 |
| Předmět: |
business.industry
digestive oral and skin physiology General Medicine Absorption (skin) Pharmacology Gastric emptying time musculoskeletal system Crossover study Peak concentration Single oral dose Sumatriptan Pharmacokinetics Concomitant Anesthesia cardiovascular system Medicine Pharmacology (medical) business medicine.drug |
| Zdroj: | Clinical Drug Investigation. 10:242-246 |
| ISSN: | 1173-2563 |
| DOI: | 10.2165/00044011-199510040-00008 |
| Popis: | The effect of sumatriptan (100mg) on the rate of absorption of paracetamol was investigated in 8 healthy volunteers in a randomised crossover study. The times to reach peak salivary paracetamol concentrations were 0.94 ± 0.33 and 2.9 ± 1.3 hours without and with sumatriptan, respectively. This delay in time to reach peak concentration was statistically significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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