Short-term Prognostic Value of Lipid Measurements in Patients with Angina pectoris
| Autor: | Gerd Assmann, Simon G. Thompson, Arnold von Eckardstein, Ignasi Bolibar |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B biology Cholesterol business.industry C-reactive protein Hematology medicine.disease Angina chemistry.chemical_compound High-density lipoprotein Endocrinology chemistry Internal medicine Hemostasis biology.protein medicine Cardiology lipids (amino acids peptides and proteins) Myocardial infarction business Lipoprotein |
| Zdroj: | Thrombosis and Haemostasis. 84:955-960 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0037-1614155 |
| Popis: | SummaryWe studied the role of various markers of lipid metabolism, hemostasis and inflammation in a two year follow-up of 3000 patients with angina pectoris, during which time 106 patients experienced myocardial infarction or sudden coronary death. Low levels of high density lipoprotein (HDL) cholesterol and of apolipoprotein (apo) A-I were most strongly associated with increased coronary risk. The relative risk per standard deviation increase was 0.68 for HDL cholesterol (95% confidence interval 0.55 to 0.84) and 0.66 for apoA-I (0.54 to 0.81). These associations were independent of other coronary risk factors, other lipid measurements, hemostatic factors, and C-reactive protein (CRP). The associations of total and LDL cholesterol, triglycerides, apoB, and lipoprotein(a) with coronary events were not independent of HDL cholesterol or hemostatic factors. We conclude that HDL cholesterol or apoA-I, hemostatic risk factors, and CRP are important prognostic markers of coronary events in secondary prevention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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