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Objectives : This study was conducted to investigate the membrane potential to apply Doksam-tang to a human heart failure model. Methods : The human heart model was built by Luo et al. CellML model, Priebe et al. CellML model, and a human heart mesh file. Doksam-tang gives channel the half maximal inhibitory concentration(IC 50 ), half maximal effective concentration(EC 50 ) values and compounds concentrations. These data load into the laptop with Ubuntu OS, and build the library with the data. Results : While results of the study with the heart failure model shows abnormal membrane potential from the normal heart model, the study with applying Doksam-tang to heart failure model shows restoring membrane potential that is similar to normal heart model. Conclusions : These results of the testings suggest that a conception of novel technique to investigate the effects of Korean herbal medicine. Keyword : heart failure, computer modelling, Doksam-tang, physiome, korean medicine, systems biology. |
