Profile of MDMA Self-Administration from a Large Cohort of Rats: MDMA Develops a Profile of Dependence with Extended Testing

Autor:	Judith Bird, Joyce Colussi-Mas, Susan Schenk, Jennifer Do
Rok vydání:	2012
Předmět:	Psychiatry and Mental health Clinical Psychology Drugs of abuse Anesthesia medicine MDMA Pharmacology Self-administration Psychology Large cohort medicine.drug Large sample
Zdroj:	Journal of Drug and Alcohol Research. 1:1-6
ISSN:	2090-8342 2090-8334
Popis:	The present study provides a profile of acqui- sition and maintenance of self-administration of +/-3,4- methylenedioxymethamphetamine (MDMA) obtained from a large cohort of rats tested during a 2 year period. Of the 128 rats, 49% self-administered 1.0 mg/kg/infusion MDMA to an initial criterion within a 25 day cut-off period. The number of test sessions required to meet this initial criterion was normally distributed around an average of 15.9 days and responding increased in a compensatory manner when the dose was decreased. In a subgroup of rats that self-administered MDMA for an additional 14 days intake increased from 8.5 to 15.25 mg/kg/day. Thus, under these conditions, MDMA is a reliable reinforcer for about half of a large sample of rats, responding is dose-dependent and acquisition of self-administration for these sensitive rats requires more test sessions than is typically used for studies examining self-administration of other drugs of abuse.
Databáze:	OpenAIRE
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