| Popis: |
Sir Thomas Lewis, in collaboration with B. Gelfand, showed in 1935 that the thrombosis produced by ergot in the cock's comb was secondary to arterial spasm. 1 This work suggested the possibility that coronary artery thrombosis in man might, at times, be precipitated by spasm of these arteries. In order to throw some light on this problem we were interested in the possibility of producing thrombosis in the coronary arteries of the cat by the use of drugs that cause arterial spasm. Among the drugs used was epinephrine. We were impressed with the ability of epinephrine in suitable doses to produce in the electrocardiogram of the intact, unanesthetized cat S-T displacement similar to that seen in the most extreme changes of coronary occlusion. We are reporting these changes in this paper. They provide confirmatory evidence of the ability of epinephrine to produce spasm of the coronary arteries and seem to offer a simple test of the ability of various drugs to cause dilatation of these arteries. |
