Layer-by-layer assembled magnetic prednisolone microcapsules (MPC) for controlled and targeted drug release at rheumatoid arthritic joints
| Autor: | Ryoji Takeda, Satoshi Ota, S. Latha, Christer Johansson, Yasushi Takemura, Chakkarapani Prabu, P. Selvamani, Fredrik Ahrentorp |
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| Rok vydání: | 2017 |
| Předmět: |
Chemistry
Layer by layer 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Polyelectrolyte 0104 chemical sciences Electronic Optical and Magnetic Materials Bioavailability chemistry.chemical_compound Adsorption Targeted drug delivery Zeta potential Particle size 0210 nano-technology Iron oxide nanoparticles Nuclear chemistry |
| Zdroj: | Journal of Magnetism and Magnetic Materials. 427:258-267 |
| ISSN: | 0304-8853 |
| DOI: | 10.1016/j.jmmm.2016.11.030 |
| Popis: | We report here in about the formulation and evaluation of Magnetic Prednisolone Microcapsules (MPC) developed in order to improve the therapeutic efficacy relatively at a low dose than the conventional dosage formulations by means of magnetic drug targeting and thus enhancing bioavailability at the arthritic joints. Prednisolone was loaded to poly (sodium 4-styrenesulfonate) (PSS) doped calcium carbonate microspheres confirmed by the decrease in surface area from 97.48 m 2 /g to 12.05 of m 2 /g by BET analysis. Adsorption with oppositely charged polyelectrolytes incorporated with iron oxide nanoparticles was confirmed through zeta analysis. Removal of calcium carbonate core yielded MPC with particle size of ~3.48 µm, zeta potential of +29.7 mV was evaluated for its magnetic properties. Functional integrity of MPC was confirmed through FT-IR spectrum. Stability studies were performed at 25 °C±65% relative humidity for 60 days showed no considerable changes. Further the encapsulation efficiency of 63%, loading capacity of 18.2% and drug release of 88.3% for 36 h and its kinetics were also reported. The observed results justify the suitability of MPC for possible applications in the magnetic drug targeting for efficient therapy of rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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