Tripodal Phosphine Oxide Ligand with Tetrazole Functionality

Autor:	Lada V. Anikina, V. A. Kochmarik, Valery K. Brel, Olga V. Bykhovskaya, T. V. Baulina, I. Yu. Kudryavtsev, M. P. Pasechnik, Anna V. Vologzhanina
Rok vydání:	2021
Předmět:	Phosphine oxide Tris chemistry.chemical_compound Chemistry Ligand chemistry.chemical_element Tetrazole General Chemistry Alkylation Medicinal chemistry Palladium
Zdroj:	Russian Journal of General Chemistry. 91:2052-2060
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363221100194
Popis:	Abstract Tris[2-(3′-cyanopropoxy)phenyl]phosphine oxide has been obtained via the alkylation of tris(2hydroxyphenyl)phosphine oxide with 4-bromobutyronitrile in the presence of K2CO3. The product structure has been elucidated by means of X-ray diffraction analysis. The terminal cyano groups in the obtained phosphine oxide have been converted into tetrazole rings via the click-reaction with NH4N3 to give a new hybrid tripodal propeller ligand, tris{2-[3′-(tetrazol-5′′-yl)propoxy]phenyl}phosphine oxide. Palladium(II) complexes of the prepared ligand and its short-linker analog, tris[2-(tetrazol-5′-ylmethoxy)phenyl]phosphine oxide, have been synthesized. Cytotoxicity of the ligands and their Pd(II) complexes has been studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8256dc4f7ddef3978665a866e203941d https://doi.org/10.1134/s1070363221100194 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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