Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients

Autor: Geoffrey A Witrak, K. Krishnan Unni, Frank J. Frassica, M. F. Schray, David C. Dahlin, Franklin H. Sim, John W. Beabout, Michael G. Rock
Rok vydání: 1986
Předmět:
Zdroj: The Journal of Bone & Joint Surgery. 68:1073-1079
ISSN: 0021-9355
DOI: 10.2106/00004623-198668070-00016
Popis: Twenty-six patients who had a malignant giant-cell tumor of bone--a sarcoma either juxtaposed to a zone of typical benign giant-cell tumor or occurring at the site of a previously documented benign giant-cell tumor--have been seen at the Mayo Clinic. Of the twenty-six tumors, nineteen were secondary to a previous attempt at local control of a benign giant-cell tumor. All but one of these nineteen patients with a secondary tumor had received therapeutic irradiation four to thirty-nine years earlier. The nature and duration of the symptoms and the sites of predilection of the malignant giant-cell tumors were the same as for benign giant-cell tumor. Fibrosarcoma occurred three times as frequently as osteosarcoma. The best results of treatment of the secondary sarcoma were obtained with early ablation.
Databáze: OpenAIRE