Nitric oxide induces endometrial secretion at implantation time
| Autor: | E. Andersson, Birgitta Byström, M. Hammarström, B. Mörlin |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Carbachol biology Obstetrics and Gynecology Secretomotor Uterine horns General Medicine Endometrium Nitric oxide Nitric oxide synthase chemistry.chemical_compound Seminal vesicle medicine.anatomical_structure Endocrinology chemistry Internal medicine medicine biology.protein Secretion medicine.drug |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 84:1029-1034 |
| ISSN: | 0001-6349 |
| Popis: | Background. Uterine cervical secretory cells receive a sympathetic cholinergic secretomotor innervation. Glandular nitric oxide (NO) production has been proposed to be a prerequisite for muscarine-induced carbohydrate secretion from endometrial glands and cervical glands at ovulation time and from the seminal vesicle glands. Nitric oxide has also been suggested to have a significant role in the process of implantation and early pregnancy in the mouse, a process, which has also been compared with an inflammatory response.Methods. The carbohydrate secretion from everted guinea pig uterine horns placed in organ baths was estimated. Polymerase chain reaction was performed in order to identify the isoforms of nitric oxide synthase (NOS).Results. Carbamylcholine chloride (Carbachol) induced carbohydrate secretion of the endometrium, whereas L-NNA and L-NAME inhibited the Carbachol-induced secretion. The isomer D-NAME had no effect on Carbachol-induced secretion. The NO donor GTN induced carbohydrate secretion o... |
| Databáze: | OpenAIRE |
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