ChemInform Abstract: Molecular Sieve Controlled Diastereoselectivity: Effect in the Palladium-Catalyzed Cyclization of cis-1,2-Divinylcyclohexane with . alpha.-Oxygen-Substituted Acids as Chiral Nucleophiles

Autor:	Peter Baeckstroem, Louise Tottie, Andreas Heumann, Joergen Tegenfeldt, Christina Moberg
Rok vydání:	2010
Předmět:	inorganic chemicals Nucleophile chemistry organic chemicals Organic chemistry chemistry.chemical_element Stereoselectivity General Medicine Molecular sieve Oxygen Medicinal chemistry Catalysis Palladium
Zdroj:	ChemInform. 24
ISSN:	0931-7597
DOI:	10.1002/chin.199314053
Popis:	Molecular sieves have been shown to improve greatly the stereoselectivity in the palladium(II)-catalyzed reaction of cis-1,2-divinylcyclohene with chiral acids. Reactions run with molecular sieves and derivatives of (R)-lactic acids as nucleophiles always yielded products with S configuration at the newly formed chiral center in contrast to reactions without molecular sieves that gave products with either S or R configuration at this chiral center. It appears that this effect has not been observed previously
Databáze:	OpenAIRE
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