A rare presentation recurrent nasopharyngeal carcinoma with axillary lymph node metastasis
| Autor: | Sethu Thakachy Subha, Zuraini Mohammad Nasir |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cisplatin
Chemotherapy medicine.medical_specialty Lung medicine.diagnostic_test business.industry medicine.medical_treatment 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology Nasopharyngeal carcinoma Positron emission tomography 030220 oncology & carcinogenesis Carcinoma medicine Surgery Radiology Stage (cooking) business Lymph node medicine.drug |
| Zdroj: | Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 20:156-158 |
| ISSN: | 2090-3405 |
| DOI: | 10.21608/ejentas.2019.12632.1109 |
| Popis: | Introduction: Nasopharyngeal carcinoma (NPC) has the highest rate of local and regional cervical lymph node re-currence amongst other head and neck epithelial malignant tumour. Distant recurrence is less common and usually occurs in bone, liver and lung. Recurrent NPC to axillary lymph node is rare.Case report: A 44-year-old male presented with two-month history of painless right axillary swelling. He was di-agnosed with nasopharyngeal carcinoma (NPC) stage IVA (T2N3M0) two years prior to presentation and had underwent neoadjuvant chemotherapy with 5-Fluorouracil and Cisplatin, and concurrent chemo-radiotherapy (CCRT) of total 70 Gy over 35 sessions with Cisplatin. He was on regular monthly surveillance reviews, with no signs of recurrence. Fine Needle Aspiration Cytology (FNAC) of the axillary swelling was reported as metastatic NPC and Positron Emission Tomography/ Com-puted tomography (PET-CT) scan showed foci of high FDG hypermetabolism at right axillary lymph node confirming the diagnosis of recurrent NPC.Conclusion: Recurrence usually occurs in the first two years after completion of treatment. Patients with an overall TNM stage IV or N3, high pre-treatment or persistently detectable post-treatment plasma EBV DNA (pEBV DNA) load are at greatest risk. Management of recurrent NPC depends on local, regional or distant recurrence. Both PET scan and pEBV DNA load can be used for relapse detection. The man-agement for each recurrent NPC case is unique and should be determined by a multidisciplinary team, local expertise and facilities. Knowledge of potential sites of recurrence is essential to both physicians and patients for early detection. |
| Databáze: | OpenAIRE |
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