A new group of 1-and 7-[ω-(benzhydryl-1-alkyl]-3methylxanthine derivatives with antihistamine activity

Autor:	S. D. Yuzhakov, E. N. Salin, N. I. Andreeva, N. M. Sazonova, V. V. Asnina, V. A. Shorr, G. F. Zhdanov, M. V. Alekseev, E. M. Dolginova, Glushkov Robert G, O. S. Fominova
Rok vydání:	2011
Předmět:	Pharmacology chemistry.chemical_classification Stereochemistry medicine.medical_treatment Pharmacology toxicology Acute toxicity Histamine receptor chemistry Group (periodic table) Drug Discovery Toxicity medicine Antihistamine Alkyl
Zdroj:	Pharmaceutical Chemistry Journal. 45
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-011-0549-3
Popis:	Directed synthesis using the accessible compound 3-methylxanthine was used to obtain a new group of 1-and 7-[ω-(benzhydryl-1)alkyl]-3-methylxanthine derivatives which functioned as histamine receptor blockers. The compound which was most active, had the longest duration of action, and the lowest toxicity was 7-[4-(4-benzhydrylpiperazinyl-1)butyl]-3-methylxanthine succinate, and this compound was selected for clinical trials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::823f8dc0fb69e7455b2217c5780a71cd https://doi.org/10.1007/s11094-011-0549-3 Zobrazit plný text záznamu Full text from SpringerLink