| Autor: |
Elli Unicomb, Mark J. Robertson, Kelly A. Young, Adam McCluskey, Christopher P. Gordon, Siobhann N. McCluskey, Mark Tarleton |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Letters in Drug Design & Discovery. 8:568-574 |
| ISSN: |
1570-1808 |
| DOI: |
10.2174/157018011795906730 |
| Popis: |
Acid-ester and acid-amide norcantharidin derivatives are prepared using a 'one-pot' synthetic procedure utilizing the ThalesNano H-cube™ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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