A Study of Tablets with a Co-Processed Dry Binder Containing Hypromellose and Α-Lactose Monohydrate

Autor:	Alena Komersová, Jitka Mužíková, P. Ondrejček, Š. Hávová, Václav Lochař
Rok vydání:	2014
Předmět:	Active ingredient chemistry.chemical_compound Materials science chemistry Chemical engineering Ultimate tensile strength Drug release Pharmaceutical Science Lactose Total energy Polyvinyl alcohol LACTOSE MONOHYDRATE Dissolution
Zdroj:	Journal of Drug Delivery Science and Technology. 24:100-104
ISSN:	1773-2247
DOI:	10.1016/s1773-2247(14)50014-7
Popis:	The paper examines the co-processed dry binder RetaLac from the aspect of its compressibility and dissolution of the active ingredient from tablets. RetaLac contains α-lactose monohydrate and hypromellose in the identical proportion. The same parameters are tested in the corresponding physical mixtures of Flowlac100 and various types of hypromellose (Metolose 100SR, Metolose 4000SR, Metolose 100000SR) and compared with the substance RetaLac. Compressibility is evaluated by means of the energy profile of compression and tensile strength of tablets. The values of the total energy of compression and plasticity were higher in the substance RetaLac than in the physical mixtures of lactose and various types of hypromellose; tablet strength, on the contrary, was lower. Dissolution profile of the active ingredient from tablets with RetaLac corresponded to the dissolution profile of tablets from a physical mixture of Flowlac 100 and Metolose 4000SR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::823111dd22642031e3d2d1177b6d861d https://doi.org/10.1016/s1773-2247(14)50014-7 Zobrazit plný text záznamu Full Text from ScienceDirect