Immunomodulatory activity ofCinnamomum zeylanicumbark
| Autor: | Samir Ramchandra Niphade, Mohammed Asad, Pradeep T. Deshmukh, Emmanuel Toppo, Gowda Kallenahalli Chandrakala |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
biology Traditional medicine Antibody titer Pharmaceutical Science General Medicine Neutropenia Levamisole medicine.disease biology.organism_classification Cinnamomum zeylanicum Complementary and alternative medicine visual_art Drug Discovery Immunology visual_art.visual_art_medium biology.protein medicine Molecular Medicine Bark Pasteurella Antibody Medicinal plants medicine.drug |
| Zdroj: | Pharmaceutical Biology. 47:1168-1173 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.3109/13880200903019234 |
| Popis: | The immunomodulatory effect of Cinnamomum zeylanicum Nees (Lauraceae), commonly known as cinnamon, was studied using different experimental models such as carbon clearance test, cyclophosphamide-induced neutropenia, neutrophil adhesion test, effect on serum immunoglobulins, mice lethality test and indirect hemagglutination test. The bark extracts were administered orally at doses of 10 and 100 mg/kg. Levamisole (2.5 mg/kg p.o.) was used as standard drug. The low dose of cinnamon bark (10 mg/kg p.o.) produced only an increase in serum immunoglobulins levels while the high dose of cinnamon bark (100 mg/kg p.o.) decreased Pasteurella multocida-induced mortality by 17%, increased the phagocytic index in carbon clearance test, increased neutrophil adhesion, increased serum immunoglobulin levels and antibody titer values. |
| Databáze: | OpenAIRE |
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