Hydrogen Exchange Reaction of Aminobenzoic Acid. I. Comparison between Wilzbach Tritiation and Acid Catalyzed Hydrogen Exchange Reaction

Autor:	Tatsuo Kondo, Toshiyasu Matsuo, Yosihiko Kasida, Mitsuyoshi Matsuo
Rok vydání:	1969
Předmět:	Hydrogen organic chemicals chemistry.chemical_element Halogenation General Chemistry General Medicine Catalysis Electrophilic substitution chemistry.chemical_compound chemistry Labelling Drug Discovery Organic chemistry Aminobenzoic acid Reactivity (chemistry) Benzoic acid
Zdroj:	Chemical and Pharmaceutical Bulletin. 17:495-498
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.17.495
Popis:	Wilzbach tritiation in ortho-, meta- and para-aminobenzoic acids was compared with acid catalysed hydrogen exchange reaction and bromination. The acid catalysed hydrogen exchange reaction of the acids in 4 N DCl occurred at ortho and para to amino group of the acids and it was confirmed that the reaction was a typical electrophilic substitution. Tritium incorporation in the acids by Wilzbach labelling was high at ortho and para to amino group of the acids although the order of reactivity on Wilzbach labelling did not completely agreed with that in acid hydrogen exchange reaction. This seems to suggest that HeT+ ion would participate in the labelling predominantly.
Databáze:	OpenAIRE
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