Genetic Variants of TNF-α, IL-1β, IL-4 Receptor α-Chain, IL-6 and IL-10 Genes Are Not Risk Factors for Sepsis in Low-Birth-Weight Infants
| Autor: | Miklós Szathmári, Barna Vásárhelyi, Erika Héninger, Tivadar Tulassay, István Kocsis, András Treszl, Ágnes Schuler |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
biology business.industry medicine.medical_treatment medicine.disease Proinflammatory cytokine Sepsis Interleukin 10 Low birth weight Endocrinology Cytokine Internal medicine Pediatrics Perinatology and Child Health Immunology medicine biology.protein Tumor necrosis factor alpha medicine.symptom business Interleukin 6 Interleukin 4 Developmental Biology |
| Zdroj: | Neonatology. 83:241-245 |
| ISSN: | 1661-7819 1661-7800 |
| Popis: | The amount of inflammatory cytokines is a major determinant for the development of sepsis in very-low-birth-weight (VLBW) neonates. We investigated whether variants of tumor necrosis factor-α, interleukin (IL)-1β, IL-4 receptor α-chain, IL-6 and IL-10 genes, associated with altered cytokine production, might influence the risk and complications of sepsis in VLBW infants. We determined the presence of these genetic variants in dried blood samples of 33 septic, 35 infected and 35 healthy VLBW neonates by PCR and RFLP methods and analyzed their association with the risk and complications of sepsis. The frequencies of genetic variants did not differ in uninfected and in infected infants with or without sepsis. Moreover, none of the studied complications was associated with carrier state of any of genetic variants. Four of the 5 septic neonates with disseminated intravascular coagulation, however, carried simultaneously the variants of IL-1β and IL-10 genes. We concluded that these genetic polymorphisms do not influence the risk and course of sepsis in VLBW neonates. |
| Databáze: | OpenAIRE |
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