Thoreliolides A and B, two polyisoprenylated benzoylphloroglucinol derivatives with a new carbon skeleton from the fruits of Calophyllum thorelii
| Autor: | Ly T.T. Nguyen, Ngan T. D. D. T. Lai, Duc M. Nguyen, Le-Thu T. Nguyen, Lien-Hoa D. Nguyen, Hieu T. Nguyen |
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| Rok vydání: | 2016 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry Organic Chemistry Carbon skeleton Sulforhodamine B Moderate activity 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences HeLa chemistry.chemical_compound chemistry Drug Discovery Calophyllum Cancer cell lines Cytotoxicity |
| Zdroj: | Tetrahedron Letters. 57:2737-2741 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2016.05.021 |
| Popis: | Thoreliolides A and B, two new polyisoprenylated benzoylphloroglucinol derivatives with a novel carbon skeleton, together with four known compounds, were isolated from the fruits of Calophyllum thorelii and their structures elucidated using spectroscopic methods. Thoreliolide B showed moderate activity against three cancer cell lines, MCF-7, HeLa and NCI-H460, with IC 50 values of 9.7, 16.6 and 24.2 μg/mL, respectively, using the sulforhodamine B assay. |
| Databáze: | OpenAIRE |
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