IMPORTANCE OF HUMAN RED CELL SURFACE STRUCTURES IN REACTIONS BETWEEN MAN AND MICROBES**Supported by National Science Foundation Grant No. GB 8378, National Institutes of Health Grant Nos. AI-05681, 05682, Atomic Energy Commission Grant No. AT(11-1) 1285, The John A. Hartford Foundation Grant No. SD-340, and the American and Chicago Heart Associations. The Immunochemistry Department is maintained by the Susan Rebecca Stone Fund.The author acknowledges the collaboration of J.C. Adye, A. Bezkorovainy, R.E. Horton, S.V. Huprikar, B. Jirgensons, J. Nichols, and H. Tegtmeyer
| Autor: | Georg F. Springer |
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| Rok vydání: | 1970 |
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| DOI: | 10.1016/b978-0-12-057050-8.50024-2 |
| Popis: | Publisher Summary This chapter describes the importance of human red-cell surface structures in reactions between man and microbes and also discusses the biological and chemical relations between the human blood-group ABH(O) glycoproteins and microbial substances with human blood-group ABH(O) specificity. Blood-group specificity is not rare among gram-negative bacteria that constitute the bulk of the human intestinal flora. The blood-group specificity of human glycoproteins is based on recurring oligosaccharide chains spread over the surface of the macromolecule. The blood-group MN erythrocyte membrane antigens and virus receptors possess some conformational order. Conformational order decreases with decreasing molecular size. Various bacterial antigens readily become attached in vitro to erythrocytes of numerous animal antigens species, including man. They can be detected on the red cells by their corresponding antibodies. Microbial antigens can coat erythrocytes in vivo under extreme conditions. |
| Databáze: | OpenAIRE |
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