Replacement of dimethylpyrazolyl group in 1,2,4,5-tetrazines by aliphatic alcohols and water

Autor:	N. I. Latosh, N. K. Ignatenko, S. G. Tolshchina, I. N. Ganebnykh, Rashida I. Ishmetova, G. L. Rusinov
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Dissociation constant Base (chemistry) chemistry Group (periodic table) Organic Chemistry Potentiometric titration Organic chemistry Medicinal chemistry
Zdroj:	Russian Journal of Organic Chemistry. 45:1102-1107
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428009070197
Popis:	Reactions of 3,6-bis(4-R-3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazines and 3-amino-6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazines with aliphatic alcohols and water in the presence of a base involved replacement of the dimethylpyrazolyl group and resulted in the formation of mono- and dialkoxy-1,2,4,5-tetrazines and 6-substituted 3-hydroxy-1,2,4,5-tetrazines. Dissociation constants of the latter were determined by potentiometric titration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::81f962a9d53754eb30876a6216e06d7a https://doi.org/10.1134/s1070428009070197 Zobrazit plný text záznamu Full text from SpringerLink