ChemInform Abstract: High-Yielding Sequential One-Pot Synthesis of Chiral and Achiral α-Substituted Acrylates via a Metal-Free Reductive Coupling Reaction

Autor:	Dhevalapally B. Ramachary, Y. Vijayendar Reddy, Chintalapudi Venkaiah
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Solvent chemistry.chemical_compound chemistry One-pot synthesis Organic chemistry Salt (chemistry) Alcohol General Medicine High yielding Coupling reaction Catalysis
Zdroj:	ChemInform. 46
ISSN:	0931-7597
DOI:	10.1002/chin.201501107
Popis:	A general process for the high-yielding synthesis of substituted chiral and achiral α-substituted acrylates was achieved through the sequential one-pot combination of a metal-free reductive coupling reaction followed by an Eschenmoser methylenation. The proline catalyzed reaction of Meldrum's acid, aldehydes and Hantzsch ester followed by methylenation was successful with Eschenmoser's salt in the presence of an alcohol solvent. Herein, we have shown the high-yielding synthesis of privileged building blocks from chiral/achiral α-substituted acrylates and shown them to be very good intermediates in the pharmaceuticals and natural products synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::81f5d30a18bac7a16c160e0712f709b6 https://doi.org/10.1002/chin.201501107 Zobrazit plný text záznamu Plný text