Diagnostic Performance of 18F-Fluorodeoxyglucose Positron Emission Tomography/CT for Chronic Empyema-Associated Malignancy
| Autor: | Jhin Gook Kim, Seung Hyup Hyun, Hojoong Kim, Young Mog Shim, Jang Yoo Yoo, Kyung Soo Lee, Joon Young Choi, Miju Cheon, Jae Il Zo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Fluorodeoxyglucose
medicine.medical_specialty PET-CT Receiver operating characteristic medicine.diagnostic_test business.industry Standardized uptake value bacterial infections and mycoses Malignancy medicine.disease Empyema respiratory tract diseases 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Positron emission tomography 030220 oncology & carcinogenesis medicine Radiology Nuclear Medicine and imaging Histopathology business Nuclear medicine medicine.drug |
| Zdroj: | Korean Journal of Radiology. 20:1293 |
| ISSN: | 2005-8330 1229-6929 |
| DOI: | 10.3348/kjr.2018.0843 |
| Popis: | OBJECTIVE The purpose of this study was to evaluate the diagnostic performance of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) for chronic empyema-associated malignancy (CEAM). MATERIALS AND METHODS We retrospectively reviewed the ¹⁸F-FDG PET/CT images of 33 patients with chronic empyema, and analyzed the following findings: 1) shape of the empyema cavity, 2) presence of fistula, 3) maximum standardized uptake value (SUV) of the empyema cavity, 4) uptake pattern of the empyema cavity, 5) presence of a protruding soft tissue mass within the empyema cavity, and 6) involvement of adjacent structures. Final diagnosis was determined based on histopathology or clinical follow-up for at least 6 months. The abovementioned findings were compared between the ¹⁸F-FDG PET/CT images of CEAM and chronic empyema. A receiver operating characteristic (ROC) analysis was also performed. RESULTS Six lesions were histopathologically proven as malignant; there were three cases of diffuse large B-cell lymphoma, two of squamous cell carcinoma, and one of poorly differentiated carcinoma. Maximum SUV within the empyema cavity (p < 0.001) presence of a protruding soft tissue mass (p = 0.002), and involvement of the adjacent structures (p < 0.001) were significantly different between the CEAM and chronic empyema images. The maximum SUV exhibited the highest diagnostic performance, with the highest specificity (96.3%, 26/27), positive predictive value (85.7%, 6/7), and accuracy (97.0%, 32/33) among all criteria. On ROC analysis, the area under the curve of maximum SUV was 0.994. CONCLUSION ¹⁸F-FDG PET/CT can be useful for diagnosing CEAM in patients with chronic empyema. The maximum SUV within the empyema cavity is the most accurate ¹⁸F-FDG PET/CT diagnostic criterion for CEAM. |
| Databáze: | OpenAIRE |
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