Highly sensitive room-temperature method of non-invasive in vivo detection of magnetic nanoparticles

Autor:	Maxim P. Nikitin, N. A. Brusentsov, Petr Mikhailovich Vetoshko, Petr I. Nikitin
Rok vydání:	2009
Předmět:	Magnetization Materials science Nuclear magnetic resonance In vivo Non invasive Nanoparticle Magnetic nanoparticles Magnetic immunoassay Condensed Matter Physics Electronic Optical and Magnetic Materials Superparamagnetism Highly sensitive
Zdroj:	Journal of Magnetism and Magnetic Materials. 321:1658-1661
ISSN:	0304-8853
DOI:	10.1016/j.jmmm.2009.02.108
Popis:	Methods of non-invasive in vivo quantification of magnetic nanoparticles (MP) have been proposed and realized. The methods are based on non-linear MP magnetization at two frequencies and measuring the response at combinatorial frequencies. The first method is developed for real-time study of MP dynamics and their clearance from the blood system of animals. High sensitivity of 3 ng of Fe 3 O 4 in 0.1 ml was achieved for MP detection in mice tail veins. The second technique is proposed for MP detection inside animal tissues by an external probe. The proposed methods could essentially widen capabilities of biomedical research which involves magnetic nanoparticles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::81e3fb5c2910def9d39333a70603ee63 https://doi.org/10.1016/j.jmmm.2009.02.108 Zobrazit plný text záznamu Full Text from ScienceDirect