Response to X-ray- and cis Pt-induced DNA damage in Stylonychia lemnae (Ciliata, Protozoa)

Autor:	Ilya Skovorodkin, Dieter Ammermann, Irina Zassoukhina, Karl-Heinz Hellmer
Rok vydání:	2003
Předmět:	Cisplatin Genetics biology Macronucleus Ciliata DNA repair DNA damage biology.organism_classification Microbiology Cell biology chemistry.chemical_compound chemistry Micronucleus test medicine Homologous recombination DNA medicine.drug
Zdroj:	European Journal of Protistology. 39:223-230
ISSN:	0932-4739
DOI:	10.1078/0932-4739-00911
Popis:	The macronuclei of the ciliated protozoan Stylonychia lemnae are highly resistant to several DNA-damaging agents, but the micronuclei are sensitive. Possible reasons for these differences were investigated. Although both kinds of nuclei continue to synthesize DNA and repair damage after application of Cisplatin, the micronuclear division rate slows down, and its DNA is degraded. Apparently only the macronuclei repair damage successfully. After treatment with X-rays, the micronuclei are lost because they are unable to divide. In the macronucleus no recombination repair was found. Our hypothesis is that the macronucleus can survive because it has enough copies of each gene to cope with the loss of some of them.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::81e2f07349437d6e02105d10b44bb079 https://doi.org/10.1078/0932-4739-00911 Zobrazit plný text záznamu Full Text from ScienceDirect