The antibacterial and antidiarreal activities of the crude methanolic Syzygium cordatum [S.Ncik, 48 (UZ)] fruit pulp and seed extracts
| Autor: | Shandu Jabulani Siyabonga, Maliehe Tsolanku Sidney, Basson Albertus Kotze |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Traditional medicine biology Pulp (paper) Extraction (chemistry) food and beverages Pharmaceutical Science Glycoside Plant Science engineering.material Syzygium cordatum biology.organism_classification Terpenoid chemistry.chemical_compound Minimum inhibitory concentration stomatognathic system Complementary and alternative medicine chemistry visual_art Betulinic acid Drug Discovery visual_art.visual_art_medium engineering Bark |
| Zdroj: | Journal of Medicinal Plants Research. 9:884-891 |
| ISSN: | 1996-0875 |
| DOI: | 10.5897/jmpr2015.5789 |
| Popis: | Diarrheal infections are the major cause of high morbidity and mortality rates, especially in the developing countries. Different parts (roots, bark and leaves) of the species Syzygium cordatum have been used as antidiarrheal extracts with the exception of its fruit-pulps and seeds. This study aimed at evaluating the antibacterial and antidiarrheal activity of S. cordatum pulp and seed extracts so to find newer and more cost-effective means to prevent diarrhoea. The harvested fruits were separated into pulp and seeds, dried and extracted with methanol using Soxhlet extraction. The extracts were screened for phytochemicals. The antibacterial and in-vivo antidiarrheal activities were determined using the microdillution method and castor oil-induced rat model, respectively. The percentage yields of 10 for fruit-pulp extract and 6 for seed extract were obtained. The detected phytochemicals were phenolics, alkaloids, cardiac glycosides, phytosterols, flavonoids, saponins, terpenoids and betulinic acid with the total phenolic content of 16.4±1.8 and 21.4±1.4 µg/mg for pulp and seed extracts, respectively. The pulp extract exhibited the lowest minimum inhibitory concentration (MIC) value of 3.13 mg/ml against some gram-positive and gram-negative bacteria while the seed extract had lowest MIC on. The in vivo antidiarrheal activity showed the percentage inhibition of 41 for the seed extract and 49 for pulp extract. The antibacterial and antidiarrheal activities were owed to the detected phytochemicals, and thus promoting S. cordatum fruit-pulps and seeds as potential sources of therapeutic compounds against diarrheal infections. Key words: Antibacterial, antidiarrheal, antimotility, phytochemicals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|