Ultrastructural Localization of the Herpes Simplex Virus Type 1 U L 31, U L 34, and U S 3 Proteins Suggests Specific Roles in Primary Envelopment and Egress of Nucleocapsids

Autor:	Richard J. Roller, Elizabeth G. Wills, Brent J. Ryckman, Joel D. Baines, Ashley E. Reynolds
Rok vydání:	2002
Předmět:	viruses Immunology Biology medicine.disease_cause Microbiology Virology Virus Cell nucleus medicine.anatomical_structure Herpes simplex virus Cytoplasm Insect Science Vero cell medicine Extracellular Nuclear protein Nuclear membrane
Zdroj:	Journal of Virology. 76:8939-8952
ISSN:	1098-5514 0022-538X
DOI:	10.1128/jvi.76.17.8939-8952.2002
Popis:	The wild-type U L 31, U L 34, and U S 3 proteins localized on nuclear membranes and perinuclear virions; the U S 3 protein was also on cytoplasmic membranes and extranuclear virions. The U L 31 and U L 34 proteins were not detected in extracellular virions. U S 3 deletion caused (i) virion accumulation in nuclear membrane invaginations, (ii) delayed virus production onset, and (iii) reduced peak virus titers. These data support the herpes simplex virus type 1 deenvelopment-reenvelopment model of virion egress and suggest that the U S 3 protein plays an important, but nonessential, role in the egress pathway.
Databáze:	OpenAIRE
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