| Autor: |
Wolberg, A. S., Getz, T. M., Uitte de Willige, S., Bergmeier, W., Walton, B. L., Lin, F.-C. |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| DOI: |
10.17615/r3xb-8174 |
| Popis: |
Elevated plasma fibrinogen associates with arterial thrombosis in humans and promotes thrombosis in mice by increasing fibrin formation and thrombus fibrin content. Fibrinogen is composed of six polypeptide chains: (Aα, Bβ, and γ)2. Alternative splicing of the γ chain leads to a dominant form (γA/γA) and a minor species (γA/γ’). Epidemiologic studies have detected elevated γA/γ’ fibrinogen in patients with arterial thrombosis, suggesting this isoform promotes thrombosis. However, in vitro data show that γA/γ’ is anticoagulant due to its ability to sequester thrombin, and suggest its expression is upregulated in response to inflammatory processes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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