Role of Lipids and Apolipoproteins in Predicting the Prognosis of Hepatocellular Carcinoma After Resection
| Autor: | Xiao-Chun Ni, Jin-Long Huang, Jie Xu, Gao Liu, Yi-Peng Fu, Wei C. Gan, Xiao-Yan Cai, Shuang-Jian Qiu, Yong Yi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hepatitis medicine.medical_specialty Multivariate analysis Apolipoprotein B biology business.industry Chronic liver disease medicine.disease Gastroenterology Resection 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Internal medicine Cohort biology.protein Medicine lipids (amino acids peptides and proteins) Pharmacology (medical) Stage (cooking) business |
| Zdroj: | OncoTargets and Therapy. 13:12867-12880 |
| ISSN: | 1178-6930 |
| DOI: | 10.2147/ott.s279997 |
| Popis: | Purpose To further clarify the association between abnormal levels of serum lipid components as the main features of dyslipidaemia and hepatocellular carcinoma, which remains unclear. Patients and Methods We examined the serum level of lipids and apolipoproteins pattern in 471 patients undergoing curative resection for HCC, 193 patients with chronic liver disease, and 104 patients with benign liver diseases. We performed uni- and multivariate analyses to evaluate the predictive roles of lipids and apolipoproteins for recurrence and survival of HCC in a training cohort of 242 patients and then validated in a cohort of 229 patients. Results The majority circulating lipid and apolipoprotein levels such as ApoA1, HDL, and LDL in chronic liver disease and HCC were slightly significantly decreased as compared to those in benign lesion. But no significant differential expression patterns of lipids and apolipoproteins were observed between chronic liver hepatitis and HCC. Multivariable analysis identified ApoA1 as a key parameter related to recurrence and survival in both training and validation cohorts. Moreover, we further demonstrated that low ApoA1 was an independent prognostic factor of poor early recurrence in two cohorts. Conclusion Although the alterations of circulating lipids and apolipoproteins were observed in HCC, none of lipids or apolipoproteins could serve as a diagnostic marker. Serum ApoA1 merits consideration as a novel prognostic marker for patients with HCC undergoing surgery since it predicts early recurrence and survival, especially for early stage patients and may improve the prognostic stratification of patients for clinical management and promote HCC clinic outcomes. |
| Databáze: | OpenAIRE |
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