Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study
| Autor: | Rong-Bin Liang, Wen-Qing Shi, Qi Lin, Yi Shao, Li-Ying Tang, Jian-Wen Fang, Qian-Min Ge, Qiu-Yu Li, Shou-Long Hu, Ting Su, Biao Li |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Resting state fMRI Receiver operating characteristic medicine.diagnostic_test business.industry Functional connectivity corneal ulcer medicine.disease 030227 psychiatry Correlation 03 medical and health sciences 0302 clinical medicine Visual cortex medicine.anatomical_structure Ophthalmology medicine In patient business Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | Neuropsychiatric Disease and Treatment. 16:1571-1581 |
| ISSN: | 1178-2021 |
| DOI: | 10.2147/ndt.s238463 |
| Popis: | Purpose To investigate differences in the functional connectivity (FC) of the primary visual cortex between patients with corneal ulcer (CU) and healthy controls (HCs) using resting-state functional magnetic resonance imaging. Patients and methods A total of 30 patients with CU and 30 HCs were closely matched in terms of sex, age, and level of education. Two-sample t-test, receiver operating characteristic curve, and Pearson's correlation coefficient analyses were used to determine the differences in FC between the two groups, the mean FC value of patients with CU and HCs, and the correlation between FC signal values and clinical manifestations in different brain regions of patients. Results The CU group showed significantly elevated FC in the left and right middle frontal gyri and lower FC with the right cuneus compared with the HC group. In addition, the FC of the right cingulate and left superior frontal gyri also increased in the CU group. The receiver operating characteristic curve revealed high diagnostic value in those brain regions. Conclusion CU involves aberrant FC of the primary visual cortex in different brain areas, including visual-related and cognitive-related regions. This finding may unveil the underlying neural mechanisms of impaired visual function in CU. |
| Databáze: | OpenAIRE |
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