Interleukin-1 beta (IL-1β) levels in gingival crevicular fluid from adults with previous evidence of destructive periodontitis

Autor: M. A. Curtis, J. M. A. Wilton, P. Critchley, J. R. Powell, J. S. Life, J. L. Mcpton, G. J. Harrap, G. S. Griffiths, N. W. Johnson
Rok vydání: 1992
Předmět:
Zdroj: Journal of Clinical Periodontology. 19:53-57
ISSN: 1600-051X
0303-6979
Popis: We have estimated the levels of Interleukin-1 beta (IL-1 beta) by ELISA in gingival crevicular fluid (GCF) at 58 sites from 37 patients with adult periodontitis. GCF was collected for 5 s on filter papers and a 2nd sample was collected for 30 s 1 min later. 68/116 strips yielded detectable levels of IL-1 beta. IL-1 beta was present in both the 1st and 2nd samples at 28 sites, in the 1st only at 4 sites and in the 2nd only at 8 sites; 18 sites were below the level of detection for the assay. When the concentrations of IL-1 beta were calculated in the original volume of GCF on each strip, the mean value for positive strips was 34.16 +/- 29.45 (SD) pg/microliters with a range from 1.75 to 97.13 pg/microliters. There were no statistically significant correlations with the plaque index, bleeding index or probable crevice depth (pocket depth). The results indicate that IL-1 is present in the GCF from a proportion of sites with evidence of previous periodontal destruction.
Databáze: OpenAIRE
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