H3 and H4 Lysine Acetylation Correlates with Developmental and Experimentally Induced Adult Experience-Dependent Plasticity in the Mouse Visual Cortex
| Autor: | Natalia Bornia, Bruno Pannunzio, Francesco Mattia Rossi, Gabriela Vierci |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Environmental enrichment biology General Neuroscience Transporter Bioinformatics Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Visual cortex medicine.anatomical_structure Histone Downregulation and upregulation Acetylation Gene expression medicine biology.protein Developmental plasticity 030217 neurology & neurosurgery |
| Zdroj: | Journal of Experimental Neuroscience. :JEN.S39888 |
| ISSN: | 1179-0695 |
| DOI: | 10.4137/jen.s39888 |
| Popis: | Histone posttranslational modifications play a fundamental role in orchestrating gene expression. In this work, we analyzed the acetylation of H3 and H4 histones (AcH3-AcH4) and its modulation by visual experience in the mouse visual cortex (VC) during normal development and in two experimental conditions that restore juvenile-like plasticity levels in adults (fluoxetine treatment and enriched environment). We found that AcH3-AcH4 declines with age and is upregulated by treatments restoring plasticity in the adult. We also found that visual experience modulates AcH3-AcH4 in young and adult plasticity-restored mice but not in untreated ones. Finally, we showed that the transporter vGAT is downregulated in adult plasticity-restored models. In summary, we identified a dynamic regulation of AcH3-AcH4, which is associated with high plasticity levels and enhanced by visual experience. These data, along with recent ones, indicate H3-H4 acetylation as a central hub in the control of experience-dependent plasticity in the VC. |
| Databáze: | OpenAIRE |
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