Novel self-assembled lithocholic acid nanoparticles for drug delivery in cancer
| Autor: | Sudipta Basu, Shrikant Shende, Sohan Patil, Sumersing Patil, Shraddha V. Jadhav, Suhas Shahaji Gawali |
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| Rok vydání: | 2013 |
| Předmět: |
Drug
Programmed cell death Lithocholic acid biology General Chemical Engineering media_common.quotation_subject Nanoparticle General Chemistry Pharmacology biology.organism_classification HeLa chemistry.chemical_compound chemistry Paclitaxel Drug delivery medicine Doxorubicin media_common medicine.drug |
| Zdroj: | RSC Advances. 3:19760 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c3ra42994f |
| Popis: | Novel versatile self-assembled nanoparticles were developed from biocompatible, biodegradable lithocholic acid derivatives. These nanoparticles can incorporate different cytotoxic drugs (paclitaxel and doxorubicin) and PI3K signalling inhibitor (PI103). Drugs were released from the nanoparticles in a slow, sustained manner at acidic pH. The drug loaded nanoparticles were internalized through lysosomal compartments and induced cell death in HeLa cervical cancer cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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