| Autor: |
Takeshi Hagino, Kazuhiro Ikegame, Hidenori Tanaka, Yoshinobu Kanda, Katsuji Kaida, Takahiro Fukuda, Yukio Kondo, Maho Sato, Noriko Doki, Hirohisa Nakamae, Ken-ichi Matsuoka, Yasuo Mori, Hideki Sano, Tetsuya Eto, Toshiro Kawakita, Yoshiko Hashii, Tatsuo Ichinohe, Yoshiko Atsuta, Junya Kanda |
| Rok vydání: |
2022 |
| Popis: |
The cut-off levels of donor-specific anti-HLA antibodies (DSAs) that are considered to predict a high risk of graft failure remain unclear. Using peripheral blood stem cell transplantation (PBSCT) data from the Japanese Society for Transplantation and Cellular Therapy/Japanese Data Center for Hematopoietic Cell Transplantation (JSTCT/JDCHCT), we examined the role of DSAs, and performed a retrospective analysis of patients whose recipients underwent related PBSCT between 2010 and 2014 with pre-transplant anti-HLA antibodies. Patients were divided into 3 groups using a mean fluorescence intensity (MFI) of 5,000 as a cut-off value: DSA positive (n = 8), anti-HLA antibody-positive (n = 137) and anti-HLA antibody-negative (n = 3657). There was a significant difference in the number of CD34-positive cells (median: 4.31, 3.97, and 5.33×106/kg, respectively; p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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