20S-Protopanaxatriol Ameliorates Hepatic Fibrosis, Potentially Involving FXR-Mediated Inflammatory Signaling Cascades
| Autor: | Ji-Xing Nan, Li-Hua Lian, Lu Gao, Yu-Chen Jiang, Xin Han, Zhong-He Hu, Zhen-Yu Cui, Jia-Yi Dou, Yue Zhu, Jian Song, Ge Wang, Yuqing Zhao, Li-Shuang Hou, Yan-Ling Wu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
biology Chemistry 010401 analytical chemistry Caspase 1 General Chemistry Pharmacology medicine.disease 01 natural sciences 0104 chemical sciences Proinflammatory cytokine Fibrosis medicine Hepatic stellate cell biology.protein Farnesoid X receptor General Agricultural and Biological Sciences Hepatic fibrosis Interleukin 6 Interleukin 1 receptor type I 010606 plant biology & botany |
| Zdroj: | Journal of Agricultural and Food Chemistry. 68:8195-8204 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | Ginseng has been used as a functional food and tonic for enhancing immune power. Here, the potential protective effect of 20S-protopanaxatriol (M4), the metabolite of protopanaxatriol, against hepatic fibrosis is investigated, which could provide nutritional interventions for disease treatment. M4 could inhibit extracellular matrix (ECM) deposition and reduce the levels of proinflammatory cytokines such as caspase 1, interleukin 1 β (IL-1β), interleukin 1 receptor type 1 (IL1R1), and interleukin 6 (IL-6). M4 also significantly increased the expression of farnesoid X receptor (FXR), suppressed the purinergic ligand-gated ion channel 7 receptor (P2X7r) signaling pathway, and works as an FXR agonist, GW4064. In thioacetamide (TAA)-induced mice, M4 could attenuate the histopathological changes and significantly regulate the expression levels of FXR and P2X7r. M4 ameliorated TAA-induced hepatic fibrosis due to the reduction of P2X7r secretion, inhibition of hepatic stellate cell (HSCs) activation, and inflammation, which were all associated with FXR activation. Hence, M4 might be useful a nutritional preventive approach in antihepatic fibrosis and antihepatic inflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|