| Autor: |
Christopher L. D. McMillan, Armira Azuar, Helle Bielefeldt-Ohmann, Gabrielle E. Kelly, Germain J. P. Fernando, David A. Muller, Ariel Isaacs, Daniel Watterson, Paul R. Young, Alberto A. Amarilla, Michael J. Landsberg, Nigel A.J. McMillan, Alexander A. Khromykh, Naphak Modhiran, Benjamin Liang, Stacey T. M. Cheung, Jovin J Y Choo, Dhruba Acharya, Adi Idris, Aroon Supramaniam |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
SARS-CoV-2 has infected over 160 million people and resulted in more than 3.3 million deaths, and we still face many challenges in the rollout of vaccines. Here, we use the high-density microarray patch to deliver a SARS-CoV-2 spike subunit vaccine directly to the skin. We show the vaccine, dry-coated on the patch is thermostable, and delivery of spike via HD-MAP induced greater cellular and antibody immune responses, with serum able to potently neutralize clinically relevant isolates including those from the B.1.1.7 and B.1.351 lineages. Finally, a single dose of HD-MAP-delivered spike provided complete protection from a lethal virus challenge, demonstrating that HD-MAP delivery of a SARS-CoV-2 vaccine is superior to traditional needle-and-syringe vaccination and has the potential to greatly impact the ongoing COVID-19 pandemic. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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