Chronic idiopathic jaundice
| Autor: | Hans Popper, Alexander Richman, Oscar Fernandez, Walter Jacobs, Murray Pizette, Robert L. Wolf, David A. Dreiling |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.diagnostic_test business.industry Cholecystography Puerto rican General Medicine Jaundice Gastroenterology Pancreatic function tests Fully developed Family member CHRONIC IDIOPATHIC JAUNDICE Internal medicine Liver biopsy medicine sense organs medicine.symptom business |
| Zdroj: | The American Journal of Medicine. 28:32-41 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(60)90220-5 |
| Popis: | Two Puerto Rican families are described, eight members of which were found to have varying amounts of hepatic cellular pigment on liver biopsy. Ten members were found to have hyperbilirubinemia. The microscopic appearance of the liver in one instance, and in another family member examined in another hospital, presented the fully developed picture of chronic idiopathic jaundice. In four instances a mild degree of pigment deposition was found and in two a borderline increase of the same pigment was noted. In one anicteric member the amount and distribution of pigment varied only slightly from the normal. It would therefore appear that some members of families with chronic idiopathic jaundice may have only a borderline increase in pigment. The conspicuous hepatic pigment demonstrated in chronic idiopathic jaundice results from accumulation of a pigment present in small amount in the centrolobular zone of normal livers. Bromsulphalein retention and oral cholecystography are not necessarily abnormal where accumulation of the pigment characteristic of chronic idiopathic jaundice is not greatly in excess, even in the presence of jaundice. Hepatic and pancreatic function tests may be entirely normal. |
| Databáze: | OpenAIRE |
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