Abstract 183: Examining the Effect of Intra-Arterial Therapy on Outcomes in IV tPA Ineligible Ischemic Stroke Patients

Autor:	Amrou Sarraj, Amelia K Boehme, Chung-Huan J Sun, Wafi Bibars, Adeola Olowu, Clark W Sitton, Emilio P Supsupin, Sheryl Martin-Schild, Rishi Gupta, James C Grotta, Sean I Savitz
Rok vydání:	2014
Předmět:	Advanced and Specialized Nursing Neurology (clinical) Cardiology and Cardiovascular Medicine
Zdroj:	Stroke. 45
ISSN:	1524-4628 0039-2499
DOI:	10.1161/str.45.suppl_1.183
Popis:	Background: Recent randomized trials (RCTs) have failed to show benefit of intra-arterial therapy (IAT) compared with patients given IV tPA alone. Many patients, however, are ineligible for IV tPA, who were not included in IMS-3, MR-RESCUE or SYNTHESIS. We investigated potential treatment effects of IAT in patients with acute ischemic stroke ineligible for tPA. Methods: In a US multicenter retrospective cohort study, we identified 476 AIS IV tPA ineligible patients with large artery occlusions (LAO) from 01/08 to 06/13. Inclusion criteria was Results: Table 1 shows baseline characteristics. Presentation >4.5 hrs (52%), high INR (11%) and recent procedure (10%) were the main reasons for IV tPA ineligibility. IAT patients had 4 times greater odds of good (OR 3.9, 95%CI 1.5-10, p=0.004) and significantly less odds of poor outcome (OR 0.3, 95%CI 0.17-0.55, p Conclusion: IAT may improve clinical outcomes in patients with LAO who are IV tPA ineligible. Testing for IAT efficacy in this patient population will require RCTs to validate our findings.
Databáze:	OpenAIRE
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