Diagnostic Value of the Acid-Labile Subunit in Acromegaly: Evaluation in Comparison with Insulin-Like Growth Factor (IGF) I, and IGF-Binding Protein-1, -2, and -31
| Autor: | Francesco Minuto, Antonina Barreca, Maura Arosio, Giovanni Faglia, Simona Garrone, Paolo Bruzzi |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
biology business.industry Endocrinology Diabetes and Metabolism Binding protein medicine.medical_treatment Growth factor Protein subunit Biochemistry (medical) Clinical Biochemistry medicine.disease Biochemistry Insulin-like growth factor-binding protein Insulin-like growth factor Basal (phylogenetics) Endocrinology Internal medicine Acromegaly Blood plasma medicine biology.protein business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 86:1091-1098 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | In normal subjects the main form of circulating insulin-like growth factor (IGF) is the 150-kDa complex. This complex is formed by the IGF peptide, the acid-stable IGF-binding protein-3 (IGFBP-3), and the acid-labile subunit (ALS). Experimental and clinical data have demonstrated that ALS is primarily under the control of GH and plays a critical role in maintaining constant levels of circulating IGF-I. In this study we evaluated ALS, IGF-I, and IGFBP-1, -2, and -3 in 45 acromegalic patients in basal conditions and, in 37 of these, twice after surgical therapy compared with 100 age- and sex-matched control subjects to estimate their value as parameter of GH secretory state. The results demonstrated that in acromegaly before treatment all parameters (ALS, 523 ± 26; IGF-I, 129 ± 6; IGFBP-1, 0.7 ± 0.1; IGFBP-3, 234 ± 21; nmol/L; mean ± sem) but IGFBP-2 were significantly different (P < 0.0001) from those in healthy subjects (ALS, 281 ± 4; IGF-I, 22 ± 1; IGFBP-1, 1.6 ± 0.1; IGFBP-3, 91 ± 3). IGF-I was more sen... |
| Databáze: | OpenAIRE |
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