Base-catalyzed heterocyclization of 2-(R-ethynyl)benzohydroxamic acids

Autor:	Dmitry S. Fadeev, S. F. Vasilevskii, T. F. Mikhailovskaya, V. I. Mamatyuk, Aleksandr A. Stepanov
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Base (chemistry) Organic Chemistry Substituent Sonogashira coupling Medicinal chemistry Benzoates Catalysis chemistry.chemical_compound Hydroxylamine chemistry Alkynylation Organic chemistry Methanol
Zdroj:	Russian Journal of Organic Chemistry. 50:506-509
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428014040101
Popis:	Sonogashira alkynylation of methyl 2-iodobenzoate with terminal acetylenes gave a series of methyl 2-(alk-1-yn-1-yl)benzoates which reacted with hydroxylamine in boiling methanol to produce five- or six-membered N-hydroxy lactams, 3-R-methylidene-2-hydroxy-2,3-dihydroisoindol-1-ones or 3-R-isoquinolin-1(2H)-ones, depending on the acetylenic substituent nature.
Databáze:	OpenAIRE
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